Searchable abstracts of presentations at key conferences in endocrinology

ea0063gp211 | Diabetes: Pharmacotherapy | ECE2019

New insights on strain-specific impacts of probiotics on insulin resistance

Kobyliak Nazarii , Falalyeyeva Tetyana , Tsyryuk Olena , Ostapchenko Liudmyla

Background and aims: Comparative animal study of efficacy of intermittent short courses administration of lyophilized single-, three- and alive multistrain probiotic on insulin resistance in rats with experimental obesity.Methods: We included 70 rats divided into 7 groups (n=10 in each). Rats of group I were intact. Newborn rats of groups II-VII were injected with monosodium glutamate (MSG) (4 mg/g). Rats of group II (MSG-obesity group) were unt...

ea0049gp60 | Cardiovascular & Lipid Endocrinology | ECE2017

Probiotics and nutraceuticals as a new frontier in obesity prevention and management

Kobyliak Nazarii , Falalyeyeva Tetyana , Bodnar Petro , Beregova Tetyana

Introduction: The beneficial interaction between the microbiota and humans is the way how bacteria contained within the gut ‘talk’ to the immune system. Into this landscape probiotics and nutraceuticals play a major role. The study aims to determine whether probiotics plus nutraceuticals such as smectite or omega-3 are superior to probiotic alone on the monosodium glutamate (MSG) induced obesity model in rats.Methods: Totally 7...

ea0070aep313 | Diabetes, Obesity, Metabolism and Nutrition | ECE2020

Omega-3 PUFA and probiotics as a single formulation for insulin resistance and obesity: Evidence from animals to randomized clinical studies

Kobyliak Nazarii , Falalyeyeva Tetyana , Mykhalchyshyn Galyna , Savchuk Olexiy , Kyriienko Dmytro , Ostapchenko Lyudmyla , Komisarenko Iuliia

Background: Probiotics and omega-3 polyunsaturated fatty acids supplementation (PUFA) have beneficial effect on obesity related disorders in animal models. We have previously shown, on rats with monosodium glutamate-induced obesity, that in take of the combination based on live probiotics and omega-3 PUFA is accompanied by the preventive effect concerning experimental obesity development, lead toinsulin resistance (IR) improvement and more obvious decrease of he paticsteatosis...

ea0099oc12.6 | Oral Communications 12: Diabetes, Obesity, Metabolism and Nutrition | Part II | ECE2024

Efficacy and safety of postbiotic supplementation for type 2 diabetes patients: Randomized clinical Ttrial (DELI Diab study)

Savytska Maryana , Baka Olena , Manzhalii Elina , Kyriienko Dmytro , Falalyeyeva Tetyana , Sichel Liubov , Kobyliak Nazarii

Background: Probiotics have beneficial effect on obesity/type 2 diabetes (T2D) related disorders in both animal models and clinical trials, at the same time, some scientific papers question the effectiveness and the safety of probiotics. In turn, postbiotics are preparations of inanimate microorganisms and / or their components, which are directly identified with the safety of their use and the health benefits of the host.Aim: To conduct placebo-controll...

ea0099ep279 | Diabetes, Obesity, Metabolism and Nutrition | ECE2024

Prediction of post-COVID syndrome development in type 2 diabetes: retrospective analysis based on national survey in Ukraine

Matviichuk Anton , Gurianov Vitalii , Yerokhovych Viktoriia , Livkutnyk Oleksandr , Falalyeyeva Tetyana , Komisarenko Iuliia , Sulaieva Oksana , Kobyliak Nazarii

Background: Post-COVID-19 condition (long COVID-19, post-acute COVID-19, long-term effects of COVID-19) is an emerging health problem in people recovering from COVID-19 infection within the past 4-6 months. Patients with type 2 diabetes (T2D) are in the risk group for a more severe course of COVID-19 and the development of its complications. Aim: to define the prevalence and prediction of post-COVID-syndrome development in patients with T2D according to ...

ea010264 | Diabetes, Obesity and Metabolism | EYES2024

Long COVID is associated with accelerated aging in type 2 diabetes patients

Yerokhovych Viktoriia , Matviichuk Anton , Ilkiv Yeva , Krasnenkov Dmytro , Korcheva Veronika , Falalyeyeva Tetyana , Sulaieva Oksana , Komisarenko Iuliia , Kobyliak Nazarii

Background and aims: Leukocyte telomere length (LTL) is considered as a promising prognostic marker associated with COVID-19 severity, adverse outcomes (hospital admission, need for critical care, respiratory support), and mortality. However, LTL contribution to long COVID development is unclear. In this study, we aimed to evaluate the relationship between LTL and long COVID development in type 2 diabetes patients (T2D) concerning clinical phenotype, gender, and biological age...

ea010266 | Diabetes, Obesity and Metabolism | EYES2024

Low mitochondrial DNA is associated with post-COVID-19 syndrome in patients with type 2 diabetes

Ilkiv Yeva , Matviichuk Anton , Yerokhovych Viktoriia , Krasnenkov Dmytro , Korcheva Veronika , Falalyeyeva Tetyana , Botsun Pavlina , Sulaieva Oksana , Komisarenko Iuliia , Kobyliak Nazarii

Introduction: Post-COVID-19 syndrome (PCS; long COVID-19, post-acute COVID-19, long-term effects of COVID-19) is an emerging health problem in people recovering from COVID-19 infection within the past 3-6 months. The study of COVID-19 severity markers and the assessment of PCS prognosis have encouraged the discovery of the molecular mechanisms responsible for PCS and inevitable pathological conditions. Aim: to define the links between mitochondrial (mt)-DNA levels in blood leu...