Endocrine Abstracts

Introduction: LADA (Latent autoimmune diabetes in adults) is an adult-onset and more indolent variety of autoimmune type 1 diabetes mellitus. In autoimmune diabetes, younger individuals typically have a rapid rate of beta-cell destruction and usually present with ketoacidosis, while adults often maintain sufficient insulin secretion to prevent ketoacidosis for many years. LADA is usually misdiagnosed initially as type 2 diabetes due to its late onset but LADA patients are anti...

Summary: Hyperuricemia is associated with glucose metabolism disorders clinically. In this study, we evaluated the relationship between serum uric acid concentrations and some insulin resistance/sensitivity parameters in Turkish type 2 diabetes mellitus patients.Methods: The anthropometric and laboratory data of 87 type 2 diabetes patients of both sexes (35 male, 52 female) were evaluated retrospectively. HOMA-IR (homeostatic model of insulin resistance)...

IntroductıonRecent studies suggest temozolomide as an effective treatment modality in invasive pituitary adenomas that did not respond to conventional treatments. In this case series, we present three cases of invasive pituitary adenomas that did not respond to conventional medical treatments and radiotherapy and were subsequently treated with temozolomide.CasesThe first patient had an invasive prolactin...

Background: Von Hippel-Lindau disease (VHL) is an autosomal dominant disease, characterized by haemangioblastomas of the retina and CNS, renal cell carcinomas (RCC) and renal cysts, pheochromocytomas, pancreatic neuroendocrine tumors and cysts, and endolymphatic sac tumors. VHL is associated with a germline mutation of the VHL tumor suppressor gene on the short arm of chromosome 3. The type-1 disease is caused by mutations, leading to severe disruption of protein acti...

Objectives: The frequency of Cushing’s disease (CD), ACTH independent Cushing’s syndrome (CS) and autonomous cortisol secretion (ACS) in patients with obesity is not well known and the results of the studies are heterogeneous. Therefore, in the present study, we aimed to assess the frequency of CD, CS, and ACS among patients with obesity.Methods: In this study, 813 consecutive patients [683 female, mean age 46.47±14.23-year-old, mean BMI 3...

Objective: Despite the high sensitivity of TRAb measured by modern assay methods, some patients with Graves’ disease (GD) may still have normal TRAb levels. Therefore, the purpose of this study was to determine the clinical utility of TRAb measured by a third generation assay method, and to determine it’s relationship with clinical and laboratory parameters in Turkish patients with GD.Methods: In this study, 328 consecutive treatment-naive pati...

Introduction: Serum parathormone (PTH) levels may remain elevated in some patients after surgery despite achievement of normal serum Ca levels. The factors contributing to this phenomenon have not been fully elucidated yet. In this study, we retrospectively analysed the data of patients whose serum Ca levels returned to normal after parathyroid surgery in our center.Patients and methods: Computer records of 35 patients who had undergone parathyroid surge...

Introduction: Mucoceles-mucus containing benign cysts of paranasal sinuses- are common with an incidence of 1% but involvement of sphenoid sinus is much less common. In this case report, we reported a patient presented with hypopituitarism after sphenoid mucocele drainage operation.Case report: A 59- year-old woman was admitted to our endocrinology out-patient clinics with a complaint of fatigue over the past 2 months. One month prior to admission, she h...

Introduction: Primary hyperparathyroidism (PHPT) is usually characterized by overproduction of parathormone (PTH) due to a solitary parathyroid adenoma. Its treatment involves surgical removal of the solitary adenoma or hyperplastic parathyroid glands that secrete PTH. Medical treatment options are used for patients with conditions that preclude surgical operation.Case presentation: A 57-year-old female patient underwent left total and right subtotal thy...

Aim: Although there are some studies regarding the effects of cigarette smoking on serum total cortisol (STC) and salivary cortisol (SaC) levels, the results are still challenging. For this purpose, we aimed to determine the effects of cigarette smoking on STC and/ or SaC levels in a small group of healthy volunteers.Study design: 15 (five female and ten male) cigarette smoker with the mean age of 39.47±14.27, and 15 age and gender matched non-smoke...