Searchable abstracts of presentations at key conferences in endocrinology

ea0049gp11 | Adrenal 2 | ECE2017

A country comparison of glucocorticoid replacement therapy in patients with primary and secondary adrenal insufficiency: data from the EU-AIR

Ekman Bertil , Quinkler Marcus , Zhang Pinggao , Zelissen Pierre , Murray Robert D.

Introduction: The daily maintenance dose of conventional hydrocortisone currently recommended by international guidelines for the management of primary adrenal insufficiency (PAI) or secondary adrenal insufficiency (SAI) is 15−25 mg/day, in 2−3 divided doses. The aim of this analysis was to investigate inter-country differences in glucocorticoid replacement doses in patients with PAI and SAI.Design: EU-AIR (ClinicalTrials.gov identifier: NCT0...

ea0049gp20 | Adrenal 2 | ECE2017

Which are the factors and causes of death in patients with adrenal insufficiency? Mortality data from EU-AIR

Quinkler Marcus , Ekman Bertil , Zhang Pinggao , Zelissen Pierre , Murray Robert D

Introduction: If untreated, adrenal insufficiency (AI) leads to premature death. Hospital record data suggest mortality associated with primary (PAI) and secondary AI (SAI) to be 2–3-fold higher than in the general population. Major causes of death include cardiovascular disease, Addisonian crises, brain tumours and infections; however, there is little further characterization of patients who died.Design: We analysed real-world data from the Europea...

ea0049ep22 | Adrenal cortex (to include Cushing's) | ECE2017

Cardiovascular risk factors do not play a role in the risk factor profile of adrenal crisis

Quinkler Marcus , Murray Robert D. , Zhang Pinggao , Zelissen Pierre , Ekman Bertil

Introduction: Adrenal crises (ACs) are life-threatening events in patients with primary (PAI) or secondary (SAI) adrenal insufficiency, occurring ~4–10 times per 100 patient-years. Major causes of ACs are infections, especially gastroenteritis and tonsillitis/laryngitis. Risk factors for ACs remain ill defined, but could include concomitant endocrine diseases (diabetes mellitus, premature ovarian failure) in PAI, diabetes insipidus in SAI, and concomitant non-endocrine di...

ea0041oc1.3 | Adrenal - Basic & Clinical | ECE2016

Hormone replacement therapy with prednisolone is associated with a worse lipid profile than replacement with hydrocortisone in patients with adrenal insufficiency: a matched analysis of data from the EU-AIR

Quinkler Marcus , Ekman Bertil , Marelli Claudio , Uddin Sharif , Zelissen Pierre , Murray Robert

Introduction: Prednisolone is the standard treatment for most inflammatory conditions. However, it is also used in hormone replacement therapy in adrenal insufficiency (AI) for historical reasons or due to its longer half-life and once-daily application. Recent data indicate that daily prednisolone could be associated with lower bone mineral density than daily hydrocortisone in patients with AI. However, data on risk factors for cardiovascular disease in patients with AI treat...

ea0038p410 | Steroids | SFEBES2015

Hormone replacement therapy with prednisolone in adrenal insufficiency patients: data from the European Adrenal Insufficiency Registry (EuAIR)

Quinkler Marcus , Ekman Bertil , Marelli Claudio , Uddin Sharif , Zelissen Pierre , Murray Robert

Introduction: Prednisolone is the standard treatment for most inflammatory conditions. However, it is also used in hormone replacement therapy in adrenal insufficiency (AI) due to historical reasons or due to its longer half-life and once daily application. Recent data showed that 5 mg daily prednisolone promotes loss in bone mineral density compared to 20 mg of hydrocortisone in patients with AI questioning the 4:1 conversion rate. Data is scarce on prednisolone treated AI pa...

ea0038p419 | Steroids | SFEBES2015

Heterogeneity in the clinical management of adrenal insufficiency – data from EU-AIR

Murray Robert , Ekman Bertil , Uddin Sharif , Marelli Claudio , Quinkler Marcus , Zelissen Pierre

Introduction: Glucocorticoid (GC) replacement therapy is administered to patients with adrenal insufficiency (AI) in multiple daily doses; however, there are no consensus guidelines on the optimal regimen.Methods: The European Adrenal Insufficiency Registry (EU-AIR) is a multinational, multicentre, observational study sponsored by Shire, initiated to monitor the long-term safety of GC replacement in patients with chronic AI. We analysed baseline data to ...

ea0037ep39 | Adrenal cortex | ECE2015

Clinical management of adrenal insufficiency shows significant heterogeneity: data from the EU-AIR study

Murray Robert D , Ekman Bertil , Jones Beverly A , Marelli Claudio , Quinkler Marcus , Zelissen Pierre

Introduction: No consensus guidelines currently exist as to the optimal glucocorticoid regimen in adrenal insufficiency (AI). In clinical practice physicians utilise a number of different glucocorticoids, usually administered in several doses throughout the day.Methods: The EU-AIR registry is a European multinational, multicentre, prospective, observational study sponsored by Shire inclusive of all patients with AI irrespective of aetiology. We analysed ...

ea0037ep71 | Adrenal cortex | ECE2015

Fludrocortisone therapy in patients with primary adrenal insufficiency: relationships with different hydrocortisone doses

Ekman Bertil , Quinkler Marcus , Jones Beverly A , Marelli Claudio , Murray Robert , Zelissen Pierre , Wahlberg Jeanette

Introduction: During recent years many authors have advocated lower hydrocortisone doses in patients with primary adrenal insufficiency (PAI) mainly due to worries for non-physiological effects like increased cardiovascular risk and bone resorption, but very little attention has been drawn to fludrocortisone dosing. Our main hypothesis was that that the higher hydrocortisone dose, the lower the fludrocortisone dose and vice versa.Design: The Eur...

ea0035p43 | Adrenal cortex | ECE2014

Detection of high rate of intercurrent illnesses and adrenal crisis in patients with adrenal insufficiency by using a patient's diary

Quinkler Marcus , Ekman Bertil , Fitts David , Marelli Claudio , Murray Robert , Zelissen Pierre

Introduction: Current understanding about the frequency of adrenal crisis in patients with adrenal insufficiency (AI) relies exclusively on retrospective data (~6.3 adrenal crisis per 100 patient-years). In addition, no data are available about the frequency of intercurrent illness events in AI patients. For the first time we prospectively used a patient’s diary in recording events of adrenal crisis and intercurrent illness in AI patients.Design: Th...

ea0035p55 | Adrenal cortex | ECE2014

Effects of adrenal insufficiency on body composition and metabolic indices: data from the European Adrenal Insufficiency Registry (EU-AIR)

Murray Robert , Ekman Bertil , Fitts David , Marelli Claudio , Quinkler Marcus , Zelissen Pierre

Introduction: Data concerning patients with adrenal insufficiency (AI) have been limited by small numbers of patients reflecting the relatively low prevalence of this disease. The European Adrenal Insufficiency Registry (EU-AIR) is a multicenter observational study of patients with both primary and secondary AI. Enrollment commenced August 2012. Comprehensive demographic data, aetiology of AI, and details of glucocorticoid replacement therapy are collected at baseline. Safety ...