ea0049gp79 | Diabetes & complications 1 | ECE2017
Crispim Daisy
, Dieter Cristine
, Lemos Natalia
, Assmann Tais
, Duarte Guilherme
, Dorfman Luiza
, Bauer Andrea
Background and Aim: Type 1 diabetes mellitus (T1DM) is an autoimmune disease resulting from the complex interaction among multiple genes, environmental factors and the immune system. Genome-wide association studies identified ERBB3 (Erb-b2 receptor tyrosine kinase 3) gene as a main susceptibility locus for T1DM. This gene encodes a member of the family of intracellular receptors of protein tyrosine kinases, which activates multiple signaling pathways including PI3K-Ak...