ea0049gp15 | Adrenal 2 | ECE2017
Fernandes-Rosa Fabio
, Boulkroun Sheerazed
, Dzib Felipe Golib
, Daniil Georgios
, Amar Laurence
, Rance Bastien
, Samson-Couterie Benoit
, Jeunemaitre Xavier
, Meatchi Tchao
, Benecke Arndt
, Strom Tim
, Zennaro Maria-Christina
Primary aldosteronism is the most common form of secondary hypertension. Somatic mutations in KCNJ5, ATP1A1, ATP2B3 and CACNA1D have been described in 50% of aldosterone producing adenomas (APA). To identify genetic alterations in new genes, we performed whole exome sequencing in 23 patients with APA negative for recurrent mutations in known driver genes. A low number of somatic variations were identified per patient, ranging from 1 to 22. N...