ea0049gp7 | Adrenal 1 | ECE2017
Vitellius Geraldine
, Delemer Brigitte
, Caron Philippe
, Bennet Antoine
, Bouligand Jerome
, Guiochon-Mantel Anne
, Viengchareun Say
, Dani Christian
, Trabado Severine
, Lombes Marc
Primary generalized glucocorticoid resistance is characterized by glucocorticoid excess without any Cushing syndrome. Patients exhibit variable clinical presentation including arterial hypertension, hirsutism or adrenal hyperplasia. Although glucocorticoid resistance has been associated with glucocorticoid receptor (GR) mutations (encoded by NR3C1 gene), only 23 mutations have been reported so far. We have conducted a French National Research Program, referred to as M...