Endocrine Abstracts

Riedel’s thyroiditis (RT) is a rare, inflammatory-sclerosing disease of the thyroid gland, with dense fibrosis that replaces normal thyroid tissue and local extension to surrounding structures causing hypothyroidism and compressive symptoms. The etiology of RT remains unknown, and its treatment is still challenging in absence of guideline consensus. We report 7 patients seen in a department of Endocrinology between 2000 and 2023: 5 women and 2 men, mean age 46 (20–81...

Introduction: Thyroid hormones are involved in the development of the fœtus and the child, and abnormal thyroid function is expected to play a role in neurodevelopmental disorders such as Attention Deficit with Hyperactivity Disorder (ADHD). The high prevalence of ADHD in patients with resistance to thyroid hormone syndrome is well documented but, surprisingly, the reported literature showed ambiguous results mostly suggesting that the thyroid function tests are normal in...

Since the emergence of the Covid-19 pandemic in 2019, a massive vaccination campaign has been undertaken around the world, and SARS-CoV-2 vaccines-induced thyroid diseases became more frequently described in the literature. Subacute thyroiditis is reported in 52 patients, mean age 45.5±1.8 years, mainly in women (n = 39), after the first (62%) or the second (38%) dose of mRNA (60%), inactivated whole-virus (25%) and adenoviral-vectored (13.5%) vaccines. The mean ti...

The primary objective of this observational study was to determine the medical practice for the management of simple goiter in France from a representative sample of general practitioners (GPs) and endocrinologists (ENDOs). As secondary objective, this study reported the incidence rate of simple goiter, toxic and non-toxic nodular goiters in France.Four hundred and sixty-nine general practitioners and 195 endocrinologists participated in the study. Eight...

Context: Familial gestational hyperthyroidism caused by mutations of TSH receptor gene, hypersensitive to hCG, is rare. Only two mutations at the same amino acid (lys183Arg, Lys183Asn) in the leucine-rich region of the extracellular N-terminal domain of the TSH receptor have been reported.Patients: A 38-year-old woman was seen during the first trimester of her second pregnancy for weight loss (5 kgs), nausea and vomiting. Thyroid function test revealed t...

Primary hypothyroidism is a frequent disease and oral levothyroxine is the mainstay of its treatment. However, more than 20% of levothyroxine-treated patients fail to achieve the recommended serum TSH level with a body weight–based dose of levothyroxine. Refractory hypothyroidism is due to either malabsorption or nonadherence. In clinical practice, a levothyroxine absorption test is part of the workup of a refractory hypothyroid patient for confirming normal levothyroxine...

SARS-CoV-2 vaccination campaigns document a satisfactory high profile of protection against Covid-19 infection, but auto-immune/inflammatory diseases have been reported following Covid-19 vaccines. A 65-year-old woman reported two days following her first dose of the BNT162b2 mRNA vaccine tearing, eye irritation, conjunctival redness, peri-orbital swelling, spontaneous hematoma of the right lower eyelid, right greater than left proptosis, with a spontaneous improvement of symp...

Introduction: Primary SMSa treatment can be associated with hormonal remission and tumor shrinkage in patients with GH-secreting pituitary adenomas. In the 2014 Endocrine Society guideline for Acromegaly, there is no specific mention of MRI follow-up during long-term SMSa treatment. The aim of this study was to evaluate any change of GH-secreting adenoma size during primary SMSa treatment and whether regular MRI follow-up was necessary in acromegalic patients treated with firs...

Thyroid-associated orbitopathy (TAO) is a classic and sometimes severe complication of autoimmune process associated with thyroid diseases, more common in Graves’ disease. Due to its functional impairment and disfiguring clinical presentation, TAO affects the quality of life of patients. Few studies have examined the importance of this impact in these patients. The main objective of this retrospective study is to determine if there is a correlation between the deteriorati...

Introduction: PRIMARYS provided evidence for TVR with monthly LAN-ATG 120 mg in treatment-naïve acromegalic patients (63% achieved TVR ≥20% with a favourable safety profile). To help clinicians with therapeutic management of acromegaly, tumour responsive over time needs to be further explored.Methods: PRIMARYS was an international, multicentre, open-label, single-arm study of 90 treatment-naïve acromegalic patients with pituitary macroade...