ea0049ep389 | Clinical case reports - Thyroid/Others | ECE2017
Oliveira-Filho Antonio F
, Dantas Irla A
, Velloso Renata N
, de Oliveira Sofia N P
, Candido Diego F F
, Nunes Adriana
Berardinelli-Seip syndrome is an autosomal recessive disorder characterized by generalized lipoatrophy, extreme insulin resistance with dyslipidaemia in childhood and development of diabetes and hepatic steatosis in adolescence. The metabolic derangements can be severe and lead to substantial comorbidities, including acute pancreatitis, hepatic cirrhosis, and premature cardiovascular disease. Other manifestations can include polycystic ovarian syndrome, acanthosis nigricans, a...