Endocrine Abstracts

Objective: Thyroid hormones are required not only for central nervous system development in the early stages of life but also play a key role in the maintenance of adult brain function. It is known that in adults, thyroid diseases can lead to various clinical manifestations i.e affective disorders, depression, memory impairment. The effects of hypothyroidism on brain functions seem particularly pronounced in depression, but until now, the mechanism underlying this relationship...

Hypersensitivity of hypothalamic–pituitary–adrenal (HPA) axis is considered to be an important factor in the pathogenesis of depression. Interestingly, glucagon-like peptide-1 (GLP-1) – an incretin hormone involved in the maintenance of glucose homeostasis in the periphery is known to activate HPA axis. The aim of the present study was to investigate whether prenatal stress (an animal model of depression) may influence levels of GLP-1 and GLP-1 receptor (GLP-1R)...