Endocrine Abstracts

Introduction: Conventional treatment of secondary hyperparathyroidism (SHP) requires supplementation of vitamin d analogues combined with calcium however several studies have reported concerns regarding the safety of calcium supplements particularly in the long term. If vitamin d without concomitant calcium supplementation is sufficient to prompt a fall in the parathyroid hormone (PTH) is still not known with certainty. The purpose of our study was to investigate if vitamin d ...

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98 years on LT4Rx witho...

Background: In the last decade, the combination of the widespread use of streptavidin-biotin technology and biotin–containing supplements (BCS) in the daily clinical practice, have led to numerous reports of erroneous hormone immunoassay results. However, there are no studies assessing the clinical and biochemical significance of that phenomenon, when treating patients with hypothyroidism. Therefore, a prospective study was designed to investigate the potential alteration...

Background: Levothyroxine (LT4) is one of the most prescribed drugs worldwide. Once started, about 90% of patients continue LT4 treatment long-term.Aim of the study: To evaluate the necessity of long-term thyroxine supplementation and to determine the prognostic factors that could identify which patients may discontinue LT4 treatment.Design and methods: LT4 replacement therapy was paused for at least six weeks in all patients conse...

Aims: While hormonal assays are commonly used for thyroid function assessment, Doppler sonography provides valuable information on vascularization and blood flow. This study aimed to examine the potential associations between Doppler parameters and clinical characteristics of hypothyroid patients, such as the autoimmune nature of the disease and adequacy of LT4 replacement.Methods: A total of 338 patients with hypothyroidism, primarily caused by autoimmu...

Introduction: Insulin resistance and diabetes have been lined to increased tumorigenesis and tumor aggressiveness in a multitude of cancers, but that link seems controversial when it comes to thyroid cancer. The present work aims to characterize the effects of various forms of diabetes [autoimmune = type 1 + LADA = DM1 vs. type 2 diabetes = DM2] on the incidence and features of tumor aggressiveness of thyroid cancers in comparison to the general population (non-diabetes = non-...

Introduction: Multiple cancers have been described more commonly in patients with diabetes, and some exhibit increased aggressiveness of the tumor as well. This association has been debated with regard to thyroid cancer. With this work, we aim to clarify whether type 2 diabetes (DM2) or autoimmunity-related diabetes (type 1 diabetes+LADA=DM1) could coexist with thyroid cancers more aggressive as compared to those found in unaffected (non-DM) individuals....

Introduction: In the thyroid gland, humoral immunity manifests with thyroid peroxidase (TPO) antibodies. In our studies, when TPO concentrations increased, thyroid cancers of follicular origin (TCFO) tended to develop less frequently.1 Other studies, though, reported an opposite trend in less aggressive cancers. The present work was designed to characterize the differential role of TPO antibodies in aggressive forms of TCFO (AGG) as compared to non-aggressive (NAG) ...

Introduction: Our previous observations suggested that high titers TPO antibodies titers limit the extent of differentiated thyroid cancer.1 Other studies found an opposite effect, especially when it comes to indolent tumors. We designed the present study to assess whether TPO antibodies have differential effects on the expansion/progression of aggressive (AGG) as opposed to non-aggressive (NAG) tumors of follicular cells origin (TCFO).Methods...