Endocrine Abstracts

Introduction: Hyperglycaemia occurs frequently in catecholamine-secreting tumours due to insulin suppression or induced insulin resistance. These changes can be reversible postoperatory (postOp).Objective: Our study aims to establish the impact of surgery in patients with catecholamine-secreting tumours upon glucose metabolism disorders, as well as the predictive factors for postOp diabetes-free patients.Methods: We retrospectively...

Introduction: The current revised medullary thyroid carcinoma (MTC) guidelines don’t specify reference ranges of basal (bCT) or stimulated serum calcitonin (sCT) levels for the diagnosis of MTC. These are important for early diagnosis and correct management.Objective: We aimed to set gender specific thresholds for bCT and sCT for MTC diagnosis.Patients and methods: CT samples during calcium-stimulation test (2...

IntroductionOver time, different substances and protocols have been used and tested for stimulating calcitonin (CT). Some of them proved to be useful in diagnosing medullary thyroid carcinoma (MTC). However, these are associated with side-effects, with various duration, intensity and severity.ObjectiveTo report the side-effects observed during CT stimulation test with calcium (Ca) gluconate.<p class="abst...

Introduction: Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor that originates from the parafollicular thyroid cells (C cells); MTC occurs as both a hereditary disease (25% of all cases), when MTC in a manifestation of multiple endocrine neoplasia type 2 or 3 (MEN 2/3) and as sporadic disease. The hereditary type is a consequence of germline mutation in the rearranged during transfection (RET) proto-oncogene, which can undergo oncogenic activation through both ...