Endocrine Abstracts

Introduction: Vicinity and adherence of hypothalamic nuclei to craniopharyngioma explain the high rate of complications and difficulties of removal of these tumors.Subjects and methods: In this retrospective study 50 patients (10 adults and 40 children or adolescents) harboring craniopharyngioma were included. These patients were operated mainly by a frontal approach. We evaluated the frequency of sleep disorders secondary to hypothalamic damage and thei...

Te paraneoplastic Cushing’s syndrome represents 9 to 18% of ACTH-dependent endogenous hypercorticisms; which poses, in clinical practice, two types of problems:– on the one hand, the differential diagnosis with Cushing’s disease, when well differentiated and morphologically undetectable endocrine tumors are involved.– on the other hand, the control of hypercortism, most often major in metastatic neuroendocri...

IntroductionParathyroid diseases are infrequent during pregnancy, but produce significant perinatal morbidity and maternal mortality if not diagnosed and properly managed. Primary hyperparathyroidism (PHP) is a rare disease in women of childbearing age. The incidence of the disease is unknown, but it is certainly rare, and most of the reported cases have been simple supplemented by a review of the literature.Case presentation<p...

Introduction: Computed tomography (CT) scan is the first imaging method used to characterize adrenal lesions in order to select patients for surgical treatment. Our aim was to specify the performance of this tool in the work up of adrenal masses (AM) recruited in a department of Endocrinology.Material and methods: This retrospective study included 100 patients hospitalized in our department between 2008 and 2014 for adrenal tumors. After a systematic exc...

Introduction: Hyponatremia’s etiological diagnosis remains a challenge in the real life. Our aim was to report a patient who was sent for severe behavioral disorders revealing hyponatremia due to an isolated deficit in aldosterone. This observation emphasizes the extreme rarity of the disease which deserves to be reported.Case report: A young patient aged 34 with a history of autoimmune thyroiditis consulted for an acute and severe psychiatric syndr...

46, XY disorders of sex development are rare diseases secondary to gonadal dysgenesis (GD) and disorders of androgens synthesis or action. Familial forms of GD are very rare; we report here the observations of two siblings with 46, XY GD.The first patient whose parents were relatives, raised as a girl consulted at 3 years for ambiguous genitalia, at clinical exam we found a small phallus, partial fusion of labio-scrotal folds with one orifice at the phal...

Erdheim Chester disease (ECD) is a non langheransian rare histiocytosis, with around 500 cases described worldwide since its discovery for the first time in 1930 by Jakob Erdheim et William Chester. It is a multivisceral disease, characterized by a proliferation of abnormal histocytes CD68 positive and CD1a negative, including a retroperitoneal and perirenal fibrosis, a peri-aortitis, an osteosclerosis of the lower limbs and sometime an exophthalmia or an diabetes insipidus. H...

Introduction: Compared to secondary amenorrhea, primary amenorrhea is deemed to be a rare condition. Our aim is to study its annual frequency during a long period of time, and to analyze its different aetiologies in an Endocrine Department.Methods: All patients referred for primary amenorrhea between 1980 and 2012 were studied. We took in account personal and family history, clinical examination, hormonal, cytogenetic and immunological assessments, and r...

Introduction: In medical practice ambiguous genitalia is a relatively are condition. The combination of two causes in genital malformation is exceptional. Our aim is to describe a person having an abnormal karyotype with a chimerism (46,XY/46,XX) and a deficit in 17β-hydroxysteroid dehydrogenase 3 (17β-HSD): an enzyme in the testes that transforms D4 Androstenedione to testosterone and androstenedione to dihydro testosterone or DHT.Case report:...

In this study, we attempted to assess the toxicity of Methyl Thiophanate (MT) on the biochemical and reproductive parameters in male Wistar rats as well as the possible protective role of Zingiber officinale (Ginger, Ging) extract against MT-induced toxicity. Hence, forty adult Wistar rats were allocated into four groups of 10 rats for each; the first group served as control, groups 2, 3 and 4 were treated orally (5/week) for 8 weeks by MT (150 mg/kg bw), Ging (100 mg...