ea0049gp58 | Cardiovascular & Lipid Endocrinology | ECE2017
van Kralingen Josie
, Anderson Cali
, Freel E. Marie
, Connell John M.
, MacKenzie Scott M.
, Davies Eleanor
Introduction: Measurement of microRNA (miRNA) in aldosterone-producing adenoma (APA) tissue from primary aldosteronism (PA) patients show levels of the miR24-1 cluster miRNAs (i.e. miRNAs 24-1, 27b and 23b) are significantly reduced relative to normal adrenal tissue. Our previous studies also show that miRNA-24 directly targets CYP11B2 (aldosterone synthase) gene expression. Circulating miRNAs released into the bloodstream may be diagnostic biomarkers or signalling mo...