Endocrine Abstracts

Introduction: The role of surgery to resect the primary lesion in incurable metastatic small intestinal (SI-NET) and pancreatic neuroendocrine tumours (P-NET) remains controversial. Recent evidence suggests that palliative surgery may increase survival even in asymptomatic patients with non-functioning tumours. The present study investigated the value of palliative resection of the primary tumour in SI-NET and P-NET by systematic literature review and meta-analysis.<p clas...

Background : Adrenocortical cancer (ACC) is a very rare but aggressive tumour with annual incidence of 2 cases per million populations. Hypercalcaemia is a commonly encountered paraneoplastic manifestation of certain cancers such as lung, breast, kidney, gynaecological and neuroendocrine tumours but very rare in ACC. So far, there are only two cases of ACC and PTHrP-related hypercalcaemia reported in the literature.Case report: 32-year-old man presented ...

Purpose: Neuroendocrine neoplasms are known to have heterogeneous biological behavior. G3 neuroendocrine tumours (NET G3) are characterized by well-differentiated morphology and Ki67>20%. The prognosis of this disease is understood to be intermediate between NET G2 and neuroendocrine carcinoma (NEC). Clinical management of NET G3 is challenging due to limited data to inform treatment strategies.Methods: We describe clinical characteristics, treatment, an...