Endocrine Abstracts

Introduction: SFRP-4 is a recently described inflammatory cytokine influencing insulin secretion from human β cells as an extracellular modulator of Wingless (Wnt) pathway. The aim of this study is to compare serum SFRP-4 levels in patients with normal glucose tolerance (NGT), impaired glucose tolerance (IGT) and type 2 diabetes (T2DM), and to investigate its relation with other parameters.Methods: The study included 152 patients who applied to the ...

Introduction: There is some evidence that a rise in the androgen hormone levels increases the risk for the development of a cardiovascular disease, obtained from the studies conducted on women with polycystic ovary and on men with androgenic alopecia. Inflammatory substances tend to increase in polycystic ovary syndrome and in androgenic alopecia. On this basis, we conducted a study that aimed to evaluate the early cardiovascular and metabolic effects in male patients with and...

Background: This study was designed to investigate prorenin and secreted frizzled-related protein-4 (SFRP-4) levels in pregnancies with or without gestational diabetes mellitus (GDM).Materials and methods: A total of 76 pregnant women were included in the study. Thirty-five of the pregnant women were included in the GDM group according to the results of oral glucose tolerance tests (OGTT) and 41 pregnant women were included in the control group.<p cl...

Androgenic alopecia (AGA) is an important clinical issue that can cause significant cosmetic problems. Many factors such as genetic, androgen hormones, environmental factors, and inflammation are involved in the pathogenesis of androgenic alopecia. Insulin and insulin resistance have been found increased in individuals with AGA. There are many proinflammatory substances which are playing role in the pathogenesis of androgenic alopecia. Secreted frizzled related protein-4 (SFRP...

Macro TSH is a large molecular-sized thyroid-stimulating hormone (TSH) that is including TSH and anti-TSH antibody. Patients with macro TSH have elevated serum TSH and normal free thyroxine levels similar to subclinical hypothyroidism. A 18-year old female patient was referred from gynecology and obstetrics to endocrinology clinic for evaluating of elevated TSH with normal free thyroxine levels. Laboratory and clinical investigations revealed that only discordant TSH levels (n...