Endocrine Abstracts

The human genome is over 2 meters in length, which has to be folded in micrometer-sized nuclear space for proper functions. Although most of our understandings in the human genome are based on linear explanations, it has been speculated that the three-dimensional (3D) and high-order organization of the genome must play important roles in framing the mechanisms of nuclear process such as transcription regulation. Recent advance in 3D genome mapping technologies and sophisticate...

We found that mast cells were present in pubertal mammary glands, and hypothesized that they participate in mammary morphogenesis and are sensitive to IGF1, which is essential for mammary development.As independently reported in another model of mast cell deficiency (Developmental Biology 2010 337 124), mast cell-deficient W/Wv mice had significantly less terminal end buds and ducts and smaller gland areas than controls at 3, 6, ...

Introduction: The management of type 1 diabetes (T1D) in young children can be extremely challenging due to high insulin sensitivity, unpredictable eating and activity and difficulty recognizing symptoms of hypoglycaemia. Continuous subcutaneous insulin infusion (CSII) therapy is beneficial in managing young children, however the small insulin doses required challenge the accuracy of standard concentration (100 IU/ml) CSII.Case report and literature revi...