ECE2024 Eposter Presentations Calcium and Bone (102 abstracts)
Morphofunctional assessment in patients with hypophosphatasia: usefulness of muscle ultrasound in the diagnosis of sarcopenia
María Del Carmen Andreo-Lopez 1 , Victoria Contreras Bolivar 1,2,3 , Enrique Moratalla-Aranda 2,4 , Trinidad González-Cejudo 2,5 , Luis Martínez-Heredia 2 , Francisco Andújar-Vera 2,6,7 , Cristina García-Fontana 1,2,3 , Beatriz García-Fontana 1,2,3 & Manuel Muñoz-Torres 1,2,3,8
1Endocrinology and Nutrition Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain; 2Institute of Biosanitary Research of Granada (ibs.GRANADA), Granada, Granada, Spain; 3CIBER on Frailty and Healthy Ageing (CIBERFES), Instituto de Salud Carlos III, Spain; 4Nuclear Medicine Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain; 5Clinical Analysis Unit, Hospital Universitario Clínico San Cecilio, Granada, Spain; 6Andalusian Institute for Research in Data Science and Computational Intelligence, Granada, Spain; 7Department of Computer Science and Artificial Intelligence, Granada, Spain; 8Department of Medicine, University of Granada, Granada, Spain
Introduction: Hypophosphatasia (HPP) presents with defective bone mineralisation secondary to a deficit of non-tissue-specific alkaline phosphatase, increasing the risk of bone fracture. Sarcopenia may increase this risk. Therefore, rapid diagnosis with accessible and cost-effective tools such as ultrasound could be useful in clinical practice. The aim was to assess the correlation of ultrasound with another validated muscle mass assessment technique.
Material and Methods: Cross-sectional study in adults with PPH. Demographic (age, sex), analytical (alkaline phosphatase-AP) and clinical variables were collected (fractures, muscle strength measured with Jamar dynamometer in kilograms (kg) -cut-off point: <p10 of Spanish population-, rectus femoris quadriceps muscle mass with ultrasound -Sonosite S-Nerve®-, fat-free mass (FFM) in kg, fat mass and bone mineral density (according to T and Z-score) by dual-energy X-ray absorptiometry (DXA). Statistical analysis was performed with IBM SPSS v.25.
Results: Thirty-three subjects were studied, 55% women aged 49±18 years and mean FA: 29±11. 52% had at least one bone fracture and 67% had dental pathology. Low muscle strength was detected in 24% (62.5% men). Mean Y-axis was 1.4±0.7, mean circumference 9±2 and mean area 4.4±2. Mean FFM was 46.5±13.5. Muscle strength was positively correlated with Y-axis (r=0.42, P=0.02), with muscle area (r=0.4, P=0.02), with T-score in femoral neck (r=0.48, P=0.01) and in lumbar spine (r=0.66, P<0.001). Pressor strength in women was associated with BMI and FFM (P=0.004). It also showed a tendency to be associated with ultrasound muscle circumference (P=0.09). Muscle area correlated positively with FFM (r=0.52, P=0.01) and negatively with fat (r=- 0.37 P=0.03).
Conclusions: Ultrasound assessment was associated with body composition and muscle function parameters. Given its accessibility, ultrasound is a useful tool to assess muscle in PPH patients, allowing an early approach to reduce the risk of osteosarcopenia.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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