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Endocrine Abstracts (2024) 99 EP563 | DOI: 10.1530/endoabs.99.EP563

1Hedi Chaker University Hospital, Dermatology, Sfax, Tunisia; 2Hedi Chaker University Hospital, Endocrinology, Sfax, Tunisia


Introduction & Objective: Hidradenitis Suppurativa (HS), or Verneuil’s disease, is a chronic suppurative inflammatory condition. This study aims to determinate the association between HS and metabolic diseases.

Materials and Methods: We conducted a retrospective study between January 2012 and December 2022 enrolling all cases of HS in our dermatology department.

Results: Over 11 years, we collected 77 cases. The average age was 39 years, with a sex ratio M/F of 4.1. Regarding lifestyle habits, 74% of patients were sedentary, and 66,2% were active smokers. The average Body Mass Index (BMI) was 26.38±4,44 [15-38.4]. Overweight and obesity were observed in 32.5% and 20.8% of patients, respectively. In our sample, 10 patients (13%) had previously diagnosed diabetes mellitus (DM), and 5 others (6.5%) were newly identified with prediabetes (fasting blood glucose between 1.1 and 1.25 g/l). Furthermore, six patients had a history of dyslipidemia (7.8%). The lipid profile indicated elevated triglyceride levels (above 1.50 g/l) in 8 cases (10.4%), elevated total cholesterol levels (above 2 g/l) in 4 cases (5.2%), and low HDL-cholesterol levels (below 0.4 g/l) in one case. Finally, 4 patients were diagnosed with hypertension (HT) (5.2%), and only one exhibited coronary insufficiency, undergoing revascularization (1.3%).

Conclusions: The significant prevalence of obesity and overweight in our HS series aligns with existing literature suggesting an association between these two conditions. Indeed, adipose tissue can release pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6, which are implicated in the pathophysiology of the dermatosis. For this reason, weight reduction is an essential non-pharmacological therapeutic approach in the management of HS. A literature review conducted in 2021 revealed that the prevalence of DM among HS patients is estimated to be between 7,1% and 20,8%. Similarly, the risk of dyslipidemia, hypertriglyceridemia, and low HDL levels is 1,4 to 4 times higher in the HS population compared to the control group. In addition, obesity and tobacco use are risk factors for HT and major adverse cardiovascular events (MACE). According to a literature review, patients with HS have a significantly higher prevalence of HT with adjusted odds ratios ranging from 1,2 to 2,1. In a cohort study, the adjusted incident risk of MACE among patients with HS is 1,5 times that of control individuals. In summary, metabolic and cardiovascular diseases constitute a cluster of comorbidities associated with HS, contributing to an increase in morbidity and mortality related to this chronic dermatosis.

Volume 99

26th European Congress of Endocrinology

Stockholm, Sweden
11 May 2024 - 14 May 2024

European Society of Endocrinology 

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