Endocrine Abstracts

Adrenocortical carcinomas (ACCs) are a group of aggressive neuroendocrine cancers that affect 1-2 people/million/year (1) and are mostly diagnosed in advanced stages. ACCs have poor overall survival (OS) rates (2). This study aimed to determine potential factors influencing OS of ACC patients in Yorkshire by a retrospective investigation of potential factors and OS of all 30 adult patients with ACC seen at St James University Hospital (SJUH) from 01/01/2000 to 01/10/2021. Analytical statistics were performed on the data. Mann-Whitney U-tests showed that female patients had an insignificantly higher median OS (50 months) than male patients (24 months; P= 0.142; U: 66.0). Mann-Whitney U-tests also showed that patients with co-morbidities had an insignificantly lower median OS (33 months) than patients without (39 months; P= 0.374; U: 103). Mann-Whitney U-tests further showed that patients with left ACC had an insignificantly higher median OS (36 months) than patients with right ACC (32 months; P= 0.689; U: 101). Furthermore, Mann Whitney U-tests showed that ACC patients with high cortisol had an insignificantly lower median OS (16.0 months) compared to that of ACC patients with low/normal cortisol (45.0 months; P= 0.412; U: 60.5). Spearman rank analyses showed that there was an insignificant reduction in OS of patients diagnosed at an older age (rs: -0.312; p: 0.0935). However, spearman rank analysis showed that there was a significant reduction in OS of more deprived patients. Overall, deprivation has been shown in this study to be the only key contributor in influencing OS of ACC patients, which is important to consider upon making treatment decisions (3).

References

1. Allolio, B., & Fassnacht, M. Clinical review: Adrenocortical carcinoma: clinical update. The Journal of clinical endocrinology and metabolism. [Internet] 2006 [cited 2022 Oct 7]; 91(6):2027–2037. Available from: doi: 10.1210/jc.2005-2639

2. Bonnet-Serrano, F., & Bertherat, J. Genetics of tumors of the adrenal cortex. Endocrine-related cancer. [Internet] 2018 [cited 2022 Oct 7]; 25(3): 131–152. Available from: doi: 10.1530/ERC-17-0361.

3. Thayaparan N. An Investigation of Potential Factors Influencing Overall Survival of Patients with Adrenocortical Carcinoma in Yorkshire. ESREP Manuscript. The University of Leeds; 2022.