Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2017) 49 EP1150 | DOI: 10.1530/endoabs.49.EP1150

ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)

Biochemical and clinical characteristics of polysystic ovarian syndrome (PCOS) in women with and without type 1 diabetes (TID)

Anjuli Gunness 1 , Agnieska Pazderska 1 , Mohamed Ahmed 1 , Niamh Phelan 1 , Gerard Boran 1 , AE Taylor 2 , MW O’Reilly 2 , Wiebke Arlt 2 , Kevin Moore 1 , Lucy-Ann Behan 1 , Mark Sherlock 1 & James Gibney 1


1Department of Endocrinology and Clinical Chemistry, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland; 2Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.


Abstract: PCOS prevalence is reported to be increased in reproductive-age women with type-1 diabetes (T1DM) but measurement of androgens, crucial for diagnosis, has been with inaccurate immunoassays. No studies have been reported using liquid-chromatography-mass-spectrometry (LCMS). Reproductive-age T1DM women attending a single centre were evaluated for PCOS (NIH criteria). Women with T1DM and PCOS (T1/PCOS) were compared to T1DM women without hyperandrogenism (T1/no HA), and to two groups of non-diabetic women with PCOS – one group BMI-matched (PCOS-lean) and the other overweight (PCOS-overweight). 16 (18%) of T1DM women had PCOS. TIDM women with PCOS compared to the overall group were younger (26.5 vs 29) and had a lower BMI (23.4 vs 25.3). Compared to T1/no HA, testosterone (1.3 vs 0.8 nM, P=0.004) and androstenedione (7.1 vs 4.6 nM, P=0.0016) were elevated but no differences in DHEA-OX, DHEAS, SHBG or free testosterone was noted. They had an older age of menarche (13 vs 12.5 years, P=0.024), and were more likely (P=0.024) to have a positive family history of PCOS. There were no differences in androgen levels between T1/PCOS and PCOS-lean women, but both of these groups demonstrated greater androstenedione levels (7.1 vs 5.5 nM, P=0.0247) than PCOS-overweight women. In summary, PCOS is common in T1DM. Women with T1/PCOS are leaner than T1 women without PCOS but are more likely to have a family history of PCOS. They have a similar biochemical phenotype to lean women with PCOS but differ from overweight women with PCOS. The mechanisms underlying PCOS in T1DM and its clinical significance are unknown.

Volume 49

19th European Congress of Endocrinology

Lisbon, Portugal
20 May 2017 - 23 May 2017

European Society of Endocrinology 

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