Endocrine Abstracts

Introduction: Acromegaly usually results from GH hypersecretion elaborated by somatotrop adenoma. The occurrence of a pregnancy in an acromegaly is an infrequent event, but better described in recent years. It could be aggravate GH secretion and tumor volume.

Objective: Describe eight pregnancies including twin pregnancy in six acromegalics patients hospitalized in the endocrinology department of the Pierre and Marie Curie center in Algiers.

Materials and method: Materials: Eight pregnancies; their mean Age was 35.5 years.meanwhile of diagnosis: MRI revealed: macro adenoma (n=7) and microadenoma (n=1); The Visual Field was normal, Hypopituitarism was observed in 1 case and thyrotoxic insufficiency in er 1 case. No diabetes mellitus or hypertension were noted. Patients underwent surgery (n=5), surgery and radiotherapy (n=1). The pregnancies were spontaneous in all cases.

Method: Diagnosis of acromegaly: HGPO/GH; GH/IGF1,magnetic RM imagining pituitary and Visual Field were performed before conception and at T1, T2, T3 of the pregnancy and in the postpartum. We have searched Diabetes Mellitus, gravid hypertension, the Childbirth Incidents, and we examinated Newborns.

Results: Eight pregnancies resulted in nine healthy babies. Gestational diabetes occurred in Three cases and regresses in the postpartum in two cases; No Gravid hypertension. The IGF1 and GH concentrations did not change significantly during pregnancy and in the postpartum. Growth adenoma was noticed in two cases but without defect in any visual field. Fetal malformations were not observed, birth weight was normal.

Conclusion: Acromegaly remains a rare cause of infertility. Pregnancy in women with active acromegaly or uncontrolled acromegaly may be associated with an increases risk of gestational and gravid hypertension. Pregnancy is occasionally associated with an enlargement of adenoma.All these data must be confirmed by prospective studies.