ECE2016 Eposter Presentations Cardiovascular Endocrinology and Lipid Metabolism (51 abstracts)
Adropin as a potential biomarker of nutrition status and cardiac function in hemodialyzed patients
Malgorzata Kaluzna , Krzysztof Schwermer , Krzysztof Hoppe , Magdalena Człapka-Matyasik , Nadia Sawicka-Gutaj , Aisha Yusuf Ibrahim , Andrzej Minczykowski , Katarzyna Piatek , Krzysztof Pawlaczyk , Katarzyna Ziemnicka & Marek Ruchala
Poznan University of Medical Science, Poznań, Poland.
Introduction: Adropin, a newly discovered peptide hormone, seems to have broad implications in energy homeostasis and metabolism in humans. Its main role is in maintaining appropriate carbohydrate and lipid economy. However, the aim of this study was to look at the novel role of adropin as a potential marker for cardiac function and nutrition status in hemodialyzed (HD) patients. To the best of our knowledge, this was the first study to consider the relationship between serum adropin concentration and clinical status of HD patients.
Description of methods/design: The study consisted of 41 HD patients (29 males; median age ±53 years). Adropin levels along with circulating N-terminal pro b-type natriuretic peptide (NT-proBNP), troponin T (cTnT), albumin (Alb), fasting serum insulin and glucose levels, insulin resistance index (HOMA-IR), insulin-like growth factor 1 (IGF-1) and parameters of lipid economy were assessed. Additionally anthropometric measurements were taken and echocardiography was performed.
Results: Adropin levels were negatively correlated with: body mass (r=−0.469), BMI (r=−0.445) and triglycerides (TAG) (r=−0.369). Also there was a significant relationship between adropin concentration and IGF-1 (r=−0.374). However adropin levels were not correlated with glucose and insulin levels and HOMA-IR. Strong positive correlations were observed between adropin level and cTnT (r=0.325) as well as NT-proBNP (r=0.355). Adropin was related to: left ventricular ejection fraction (LVEF) (r=−0.499) and left ventricular systole (LVS) diameter (r=0.451). No correlation was found between adropin and blood pressure.
Conclusion: Adropin seems to be a negative predictor of nutrition in HD patients. The relationship between adropin and markers of cardiac insufficiency might indicate a new link between myokines and cardiovascular disease in dialyzed patients. Adropin could potentially be a new candidate for a marker of cardiac insufficiency in HD patients.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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