ECE2016 Eposter Presentations Thyroid (non-cancer) (120 abstracts)
Relationship to TSH, and interleukin levels patients with Hashimoto’s Thyroiditis
Bedia Guleryuz 1 , Fulya Akin 2 , Senay Topsakal 2 , Guzin Fidan Yaylalı 2 , Sebahat Turgut 3 , Melek Tunç Ata 3 & Mukaddes Mergen Dalyanoglu 3
1Department of Internal Medicine, Faculty of Medicine, Pamukkale University, Kinikli Campus, Denizli, 20070, Turkey; 2Department of Endocrinology and Metabolism, Faculty of Medicine, Kinikli Campus, Denizli, 20070, Turkey; 3Department of Physiology, Faculty of Medicine, Pamukkale University, Kinikli Campus, Denizli, 20070, Turkey.
Background: Hashimoto’s Thyroiditis (HT) is the most common clinical expression of thyroid dysfunction and result from organ-specific autoimmune reaction. Cytokines are play an important role in autoimmunity, by stimulating B and T cells.
The aim of this study is to examine the relationship between cytokines and thyroid function tests in patient with Hashimoto’s Thyroiditis
Methods: 139 cases with HT included this study. Subjects were recruited from Endocrinology Clinic of Pamukkale University in Turkey. Serum levels of sT3 (pg/ml) sT4(ng/dl) TSH (μIU/ml) were measured and IL-4, IL-5, TNF-α, IFN-γ analysis were performed with Elisa kits.
Results: IL-4, and IFN-γ levels were significantly correlated with TSH levels. (P<0.01)TNF-α level was correlated with TSH levels, but was not statistically significant. IL-2 and IL-5 were not correlated with TSH levels.
Conclusion: Studies shows that there is a relationship between thyroid function tests with cytokines.In thyroidal and nonthyroidal diseases that occur during thyroid dysfunction, it is considered that can be realized through cytokines. In our study we observed a correlation between thyroid function and cytokines, and we believe that supports this view.
Keywords: TSH, IL-2, IL-4, IL-5, IFN-γ, TNF-α Levels, Hashimoto’s Thyroiditis.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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