ECE2015 Eposter Presentations Thyroid cancer (90 abstracts)
Graves' disease and papillary/insular thyroid cancer in a large compressive goitre
Mara Carsote 1, , Anda Dumitrascu 2 , Dana Terzea 2, , Andreea Geleriu 2 , Dan Peretianu 3 , Daniela Alexandrescu 2, , Corina Chirita 6 , Radu Iorgulescu 5 , Andrei Goldstein 2 & Catalina Poiana 1,
1C. Davila University of Medicine and Pharmacy, Bucharest, Romania; 2C.I. Parhon National Institute of Endocrinology, Bucharest, Romania; 3SCM Povernei Medical Centre, Bucharest, Romania; 4St John Hospital, Bucharest, Romania; 5Monza Oncoteam Hospital, Bucharest, Romania; 6Anima Medical Centre, Bucharest, Romania.
Introduction: The association between autoimmune thyroid disease and thyroid cancer is a dynamic field regarding the prevalence data and the common pathogenic background.
Aim: We report a sixth decade women case with a 1 year history of Graves’ disease that was discovered with an aggressive differentiated thyroid carcinoma.
Case report: M.E. 56-year-old female has a 10 months history of daily medium dose of thyamazolum which was well tolerated (she presented with mild features of hyperthyroidism). The personal and family medical history is negative. On admission, she accused compressive symptoms for the last 2 months. The TSH was 1.59 μUI/ml. The eye examination showed values of 17 mm for proptosis. The cervical computed tomography pointed a large left thyroid nodule of 4.5 by 7.28 cm, with multiple microcalcifications associating a mass effect over the trachea (the minimum diameter of 1.71 by 1.7 cm at the level of clavicles). The eye exam showed values of 17 mm for exophthalmometria. The calcitonin was normal (of 0.857 pg/ml), as well as antithyreoperoxidase antibodies (of 14 U/ml). The total thyroidectomy and lymph neck resection was performed. A papillary thyroid carcinoma (oxifile type) with insular and compact areas was found (of 6 cm), together with vessel invasion (T3N1Mo). The immunohistochemistry pointed a Ki67 of 15%. The 131 iodine therapy was added to the levothyroxine suppressive therapy.
Conclusion: The finding of a follicular cells cancer in a thyroid underling an autoimmune process is a rare event, yet new data reveals that the two diseases maybe more than incidental, possible by sharing common mechanisms.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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