ECE2013 Poster Presentations Bone and Osteoporosis (41 abstracts)
Vertebral fractures in women with postmenopausal osteoporosis with or without prior fragile fracture
Jovanka Novakovic-Paro , Branka Kovacev-Zavisic , Milena Mitrovic , Dragana Tomic-Naglic , Ivana Bajkin , Tijana Icin , Radoslav Pejin , Dragan Tesic , Damir Benc & Milica Medic-Stojanoska
Clinic for Endocrinology, Diabetes and Metabolic Disorders, Clinical Centre of Vojvodina, Novi Sad, Vojvodina, Serbia.
Introduction: Vertebral fragile fracture is risk factor for future vertebral and hip fractures.
Aim: To establish prevalence of vertebral fractures using lateral DXA scan of thoracic and lumbar spine in women with postmenopausal osteoporosis.
Method: Study comprised 73 women with postmenopausal osteoporosis diagnosed using spine and hip DXA. Vertebral fractures were verified by lateral DXA scan vertebral morphometry of thoracic and lumbar spine.
Results: 37 (50.7%) women had prior non-vertebral fragile fracture (group A) and 36 (49.3%) did not (group B). Group A had fractures as follows: 26 (70.3%) distal radius, 2 (5.4%) hip, 3 (8.1%) ribs, 2 (5.4%) proximal humerus, 4 (10.8%) distal fibula. There was not tatistically significant difference in age and BMI between two groups (67.24±7.81 vs 67.58±10.28 years; BMI: 26.42±3.94 vs 24.76±3.94 kg/m2). Average T-scores in group A were: L1–L4 −2.5 S.D., femur neck −1.83 S.D., hip −1.94%. In group B: L1–L4 −3.2 S.D., femur neck −2.3 S.D. and hip −2.27 S.D. There was statistically significant difference of L1–L4 T-score among groups (group A −2.5; group B −3.2; P<0.005). In group A 7 (18.9%) women did not have vertebral fracture, 9 (24.3%) one, 21 (56.7%) two or more and 7 (18.9%) five. In group B 8 (22.2%) had no vertebral fractures, 8 (22.2%) one, 20 (55.5%) two or more, and 11 (30.5%) had two vertebral fractures. In both groups thoracic vertebrae fractures of second degree were more frequent, with similar frequency of compressive and wedge fractures. Women in group A had statistically significant higher frequency of vertebral fractures (P<0.05) and lumbar vertebrae fractures (P<0.05).
Conclusion: Women with prior fragile fracture have greater frequency and more vertebral fractures, with lumbar vertebrae fractures with repercussions on BMD. Lateral DXA scan helps in spine and hip DXA BMD interpretation and individual fracture risk estimation.
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Endocrine Abstracts
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